Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics

Dobiecki-Davies, J 2021, Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics , MSc by research thesis, University of Salford.

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Abstract

DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest. A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients.

Item Type: Thesis (MSc by research)
Contributors: Wilkinson, JA (Supervisor)
Schools: Schools > School of Environment and Life Sciences
Funders: Kidscan
Depositing User: Josef Dobiecki-Davies
Date Deposited: 05 Oct 2021 13:53
Last Modified: 05 Oct 2021 13:53
URI: http://usir.salford.ac.uk/id/eprint/61550

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