SnoRNAs and miRNAs networks underlying COVID-19 disease severity

Parray, A, Mir, FA ORCID: https://orcid.org/0000-0003-1104-0852, Doudin, A, Iskandarani, A, Danjuma, IMM ORCID: https://orcid.org/0000-0003-2198-5278, Kuni, RAT, Abdelmajid, A, Abdelhafez, I ORCID: https://orcid.org/0000-0002-3050-9057, Arif, R, Mulhim, M, Abukhattab, M, Dar, SR, Moustafa, A-EA ORCID: https://orcid.org/0000-0003-4452-3439, Elkord, E ORCID: https://orcid.org/0000-0002-3868-0318, Al Khal, AL, Elzouki, A-N and Cyprian, F 2021, 'SnoRNAs and miRNAs networks underlying COVID-19 disease severity' , Vaccines, 9 (10) , e1056.

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Abstract

There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers of COVID-19 severity. Using differential expression analysis of microarray data (n = 29), we identified hsa-miR-1246, ACA40, hsa-miR-4532, hsa-miR-145-5p, and ACA18 as the top five differentially expressed transcripts in severe versus asymptomatic, and ACA40, hsa-miR-3609, ENSG00000212378 (SNORD78), hsa-miR-1231, hsa-miR-885-3p as the most significant five in severe versus mild cases. Moreover, we found that white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil (%), lymphocyte (%), red blood cell (RBC) count, hemoglobin, hematocrit, D-Dimer, and albumin are significantly correlated with the identified differentially expressed miRNAs and snoRNAs. We report a unique miRNA and snoRNA profile that is associated with a higher risk of severity in a cohort of SARS-CoV-2 infected patients. Altogether, we present a differential expression analysis of COVID-19-associated microRNA (miRNA)/small nucleolar RNA (snoRNA) signature, highlighting their importance in SARS-CoV-2 infection.

Item Type: Article
Contributors: Sautto, GA (Editor), Diotti, RA (Editor) and Abreu, RB (Editor)
Additional Information: ** From MDPI via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2076-393X **History: published 23-09-2021; accepted 19-09-2021
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Vaccines
Publisher: MDPI
ISSN: 2076-393X
Related URLs:
Funders: Qatar University
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 27 Sep 2021 12:20
Last Modified: 27 Sep 2021 12:30
URI: http://usir.salford.ac.uk/id/eprint/61916

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