Facile synthesis and biological evaluation of chrysin derivatives

Omonga, NF, Zia, Z, Ghanbour, HA, Ragazzon-Smith, AH, Foster, HA, Hadfield, JA ORCID: https://orcid.org/0000-0001-7984-8319 and Ragazzon, PA 2021, 'Facile synthesis and biological evaluation of chrysin derivatives' , Journal of Chemical Research, 45 (11-12) , pp. 1083-1092.

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Abstract

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,4-dinitrophenoxy)-5-hydroxy-3-phenyl-4H-chromen-4-one (C3) was shown to be extremely active on bacterial strains methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae as well as having anticancer activity on a range of cancer cell lines with IC50 values less than 30 µM. Chrysin has been known for their anticancer and antimicrobial properties, and this study not only corroborates this but also shows that it is possible to synthesise new improved derivatives with therapeutic possibilities.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Journal of Chemical Research
Publisher: SAGE Publications
ISSN: 1747-5198
Related URLs:
Funders: Nigerian Government, University of Salford
Depositing User: JA Hadfield
Date Deposited: 06 Dec 2021 12:16
Last Modified: 15 Feb 2022 16:58
URI: http://usir.salford.ac.uk/id/eprint/62485

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