Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3/blood) based drug delivery through a bell-shaped occluded artery with Joule heating, viscous dissipation and variable viscosity effects

Ghandi, R, Sharma, BK, Kumawat, C and Beg, OA ORCID: https://orcid.org/0000-0001-5925-6711 2022, 'Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3/blood) based drug delivery through a bell-shaped occluded artery with Joule heating, viscous dissipation and variable viscosity effects' , Proceedings of the Institution of Mechanical Engineers, Part E : Journal of Process Mechanical Engineering, 236 (5) , pp. 2024-2043.

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Abstract

The present work deals with the impact of hybrid nanoparticles (Au-Al2O3/Blood) on the blood flow pattern through a porous cylindrical artery with bell-shaped stenosis in the presence of an external magnetic field, Joule heating, and viscous dissipation by considering twodimensional pulsatile blood flow. The temperature-dependent viscosity model is utilized in this model. The blood flow is assumed to be unsteady, laminar, viscous, and incompressible. The mild stenotic presumption normalizes and reduces the bi-directional flow to uni-directional. The Crank-Nicolson scheme is applied to solve the continuity, momentum, and energy equations with appropriate initial and boundary conditions. The acquired results of the work are presented graphically. They have been examined for several values of the dimensionless parameters such as Magnetic number (M2 ), Darcy number (Da), Grashof number (Gr), viscosity parameter (β0), Reynolds number (Re), Eckert Number (Ec), Prandtl number (Pr), different concentration of both the nanoparticles (φ1, φ2), and pressure gradient parameter (B1). The velocity contours for different emerging parameters have been drawn to analyze the overall behavior of blood flow patterns. The non-dimensional velocity profile enhances with increment in values of Da, implying that the medium’s permeability provides less barrier to flow. The cumulative impact of Joule Heating and viscous dissipation are discussed. It demonstrates that increasing viscous dissipation (Ec) and Joule heating (M2 ) parameter simultaneously raise the nanofluid temperature since the mechanical energy is transformed to thermal energy within molecules, which causes a hike in temperature. The findings reveal that hybrid nanoparticles (Au-Al2O3/blood) effectively reduce hemodynamic variables such as wall shear stress and resistance impedance. Results indicate that nanoparticles may be helpful to keep the blood velocity under control and allow the surgeons to adjust it as and when required. The present work aims to get insight into the treatment of atherosclerosis without surgery, lower medical costs, and reduce post-surgical complications. Also, it has broad implications in treating various conditions, including cancers, infections, and the removal of blood clots. The current findings are consistent with recent findings in earlier blood flow research studies.

Item Type: Article
Schools: Schools > School of Computing, Science and Engineering
Journal or Publication Title: Proceedings of the Institution of Mechanical Engineers, Part E : Journal of Process Mechanical Engineering
Publisher: SAGE Publishing
ISSN: 0954-4089
Related URLs:
Depositing User: OA Beg
Date Deposited: 26 Jan 2022 11:59
Last Modified: 14 Sep 2022 14:15
URI: https://usir.salford.ac.uk/id/eprint/62852

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