Aspergillus fumigatus —host interactions mediating airway wall remodelling in asthma

Namvar, S ORCID: https://orcid.org/0000-0001-5571-368X, Labram, B, Rowley, J and Herrick, S ORCID: https://orcid.org/0000-0002-9085-5664 2022, 'Aspergillus fumigatus —host interactions mediating airway wall remodelling in asthma' , Journal of Fungi, 8 (2) , e159.

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Abstract

Asthma is a chronic heterogeneous respiratory condition that is mainly associated with sensitivity to airborne agents such as pollen, dust mite products and fungi. Key pathological features include increased airway inflammation and airway wall remodelling. In particular, goblet cell hyperplasia, combined with excess mucus secretion, impairs clearance of the inhaled foreign material. Furthermore, structural changes such as subepithelial fibrosis and increased smooth muscle hypertrophy collectively contribute to deteriorating airway function and possibility of exacerbations. Current pharmacological therapies focused on airway wall remodelling are limited, and as such, are an area of unmet clinical need. Sensitisation to the fungus, Aspergillus fumigatus, is associated with enhanced asthma severity, bronchiectasis, and hospitalisation. How Aspergillus fumigatus may drive airway structural changes is unclear, although recent evidence points to a central role of the airway epithelium. This review provides an overview of the airway pathology in patients with asthma and fungal sensitisation, summarises proposed airway epithelial cell−fungal interactions and discusses the initiation of a tissue remodelling response. Related findings from in vivo animal models are included given the limited analysis of airway pathology in patients. Lastly, an important role for Aspergillus fumigatus-derived proteases in triggering a cascade of damage-repair events through upregulation of airway epithelial-derived factors is proposed.

Item Type: Article
Contributors: Perlin, DS (Editor)
Additional Information: ** From MDPI via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2309-608X **History: published 06-02-2022; accepted 01-02-2022
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Journal of Fungi
Publisher: MDPI
ISSN: 2309-608X
Related URLs:
Funders: Medical Research Council (MRC)
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 08 Feb 2022 10:17
Last Modified: 15 Feb 2022 16:47
URI: http://usir.salford.ac.uk/id/eprint/63108

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