Promising use of immune cell‐derived exosomes in the treatment of SARS‐CoV‐2 infections

Alahdal, M ORCID: https://orcid.org/0000-0003-1444-6014 and Elkord, E ORCID: https://orcid.org/0000-0002-3868-0318 2022, 'Promising use of immune cell‐derived exosomes in the treatment of SARS‐CoV‐2 infections' , Clinical and Translational Medicine, 12 (8) .

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Abstract

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is persistently threatening the lives of thousands of individuals globally. It triggers pulmonary oedema, driving to dyspnoea and lung failure. Viral infectivity of coronavirus disease 2019 (COVID‐19) is a genuine challenge due to the mutagenic genome and mysterious immune‐pathophysiology. Early reports highlighted that extracellular vesicles (exosomes, Exos) work to enhance COVID‐19 progression by mediating viral transmission, replication and mutations. Furthermore, recent studies revealed that Exos derived from immune cells play an essential role in the promotion of immune cell exhaustion by transferring regulatory lncRNAs and miRNAs from exhausted cells to the active cells. Fortunately, there are great chances to modulate the immune functions of Exos towards a sustained repression of COVID‐19. Engineered Exos hold promising immunotherapeutic opportunities for remodelling cytotoxic T cells’ function. Immune cell‐derived Exos may trigger a stable epigenetic repression of viral infectivity, restore functional cytokine‐producing T cells and rebalance immune response in severe infections by inducing functional T regulatory cells (Tregs). This review introduces a view on the current outcomes of immunopathology, and immunotherapeutic applications of immune cell‐derived Exos in COVID‐19, besides new perspectives to develop novel patterns of engineered Exos triggering novel anti‐SARS‐CoV‐2 immune responses.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Clinical and Translational Medicine
Publisher: Wiley Open Access
ISSN: 2001-1326
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 06 Sep 2022 13:37
Last Modified: 06 Sep 2022 13:45
URI: http://usir.salford.ac.uk/id/eprint/64616

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