Myeloid-derived suppressor cells in colorectal cancer: prognostic biomarkers and therapeutic targets

Al-Mterin, MA ORCID: and Elkord, E ORCID: 2022, 'Myeloid-derived suppressor cells in colorectal cancer: prognostic biomarkers and therapeutic targets' , Exploration of targeted anti-tumor therapy, 3 (4) , pp. 497-510.

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Myeloid-derived suppressor cells (MDSCs) are a group of immature myeloid cells, which are expanded in most cancer patients. MDSCs suppress host immune responses, leading to cancer growth and progression. Several studies demonstrated that there was a relationship between levels of MDSCs and tumorigenesis in colorectal cancer (CRC) patients. MDSCs are now being investigated for their role as possible therapeutic targets in cancer treatment. This review summarizes available studies that investigated MDSC expansion in CRC patients, as well as their role in CRC tumorigenesis, prognosis, and targeting. Based on the available studies, there is a possible relationship between high levels of MDSCs and CRC progression. Additionally, targeting MDSCs in CRC patients selectively represents a significant challenge for the development of targeted treatments. Targeting of MDSCs could be exploited in different ways including MDSC depletion, inhibition of MDSC function and recruitment, and enhancing MDSC differentiation. Overall, MDSCs could be exploited as prognostic biomarkers and potential therapeutic targets in CRC. [Abstract copyright: © The Author(s) 2022.]

Item Type: Article
Schools: Schools > School of Health and Society
Journal or Publication Title: Exploration of targeted anti-tumor therapy
Publisher: Open Exploration
ISSN: 2692-3114
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 10 Oct 2022 14:03
Last Modified: 10 Oct 2022 14:15

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