Copper tolerance in bacteria requires the activation of multiple accessory pathways

Giachino, A ORCID: https://orcid.org/0000-0002-7725-1065 and Waldron, KJ 2020, 'Copper tolerance in bacteria requires the activation of multiple accessory pathways' , Molecular Microbiology, 114 (3) , pp. 377-390.

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Abstract

Copper is a required micronutrient for bacteria and an essential cofactor for redox-active cuproenzymes. Yet, excess copper is extremely toxic, and is exploited as a bacteriocide in medical and biotechnological applications and also by the mammalian immune system. To evade copper toxicity, bacteria not only control intracellular copper homeostasis, but they must also repair the damage caused by excess copper. In this review, we summarize the bacterial cell-wide response to copper toxicity in Enterobacteria. Tapping into the abundant research data on two key organisms, Escherichia coli and Salmonella enterica, we show that copper resistance requires both the direct copper homeostatic response and also the indirect accessory pathways that deal with copper-induced damage. Since patterns of copper response are conserved through the Proteobacteria, we propose a cell-wide view of copper detoxification and copper tolerance that can be used to identify novel targets for copper-based antibacterial therapeutics.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Molecular Microbiology
Publisher: Wiley
ISSN: 1365-2958
Depositing User: A Giachino
Date Deposited: 01 Nov 2022 08:49
Last Modified: 01 Nov 2022 09:00
URI: https://usir.salford.ac.uk/id/eprint/65422

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