The United Kingdom paediatric critical care society study group: the 20-year journey toward pragmatic, randomized clinical trials

Peters, MJ, Ramnarayan, P, Scholefield, BR, Tume, LN ORCID: https://orcid.org/0000-0002-2547-8209 and Tasker, RC 2022, 'The United Kingdom paediatric critical care society study group: the 20-year journey toward pragmatic, randomized clinical trials' , Pediatric Critical Care Medicine .

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Abstract

Over the past two decades, pediatric intensive care research networks have been formed across North America, Europe, Asia, and Australia/New Zealand. The U.K. Paediatric Critical Care Society Study Group (PCCS-SG) has over a 20-year tradition of fostering collaborative research, leading to the design and successful conduct of randomized clinical trials (RCTs). To date, the PCCS-SG network has delivered 13 different multicenter RCTs, covering a spectrum of study designs, methodologies, and scale. Lessons from the early years have led PCCS-SG to now focus on the entire process needed for developing an RCT, starting from robust preparatory steps such as surveys, data analysis, and feasibility work through to a definitive RCT. Pilot RCTs have been an important part of this process as well. Facilitators of successful research have included the presence of a national registry to facilitate efficient data collection; close partnerships with established Clinical Trials Units to bring together clinicians, methodologists, statisticians, and trial managers; greater involvement of transport teams to recruit patients early in trials of time-sensitive interventions; and the funded infrastructure of clinical research staff within the National Health Service to integrate research within the clinical service. The informal nature of PCCS-SG has encouraged buy-in from clinicians. Greater international collaboration and development of embedded trial platforms to speed up the generation and dissemination of trial findings are two key future strategic goals for the PCCS-SG research network. [Abstract copyright: Copyright © 2022 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.]

Item Type: Article
Schools: Schools > School of Health and Society
Journal or Publication Title: Pediatric Critical Care Medicine
Publisher: Lippincott, Williams & Wilkins
ISSN: 1529-7535
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 07 Dec 2022 14:46
Last Modified: 07 Dec 2022 14:46
URI: https://usir.salford.ac.uk/id/eprint/65752

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