Mitchell, A, Wall, JE, Murray, JG and Morgan, CG 2002, 'Direct modulation of the effective sensitivity of a CCD detector: a new approach to time-resolved fluorescence imaging' , Journal of Microscopy, 206 (3) , pp. 225-232.
Full text not available from this repository. (Request a copy)Abstract
In this paper a novel approach to frequency-domain fluorescence lifetime imaging (FLIM) is described. In a CCD camera a single pixel is defined by a charge pattern on a group of electrodes. By modulation of the pattern of voltages defining the pixel structure it is possible to modulate the sensitivity of the CCD at radio frequency. The modulation enhances the noise performance of the CCD, in contrast to the deterioration in performance seen when an intensifier stage is similarly modulated. The new technology has potential applications to a wide range of assays as well as in conventional FLIM applications. Unlike intensifier-based systems, the directly modulated CCD is physically small, inexpensive, robust and offers superior resolution and noise performance.
| Item Type: | Article |
|---|---|
| Themes: | Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > Q Science > QC Physics Subjects outside of the University Themes |
| Schools: | Schools > School of Environment and Life Sciences Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | Journal of Microscopy |
| Publisher: | Blackwell Publishing |
| Refereed: | Yes |
| ISSN: | 00222720 |
| Depositing User: | H Kenna |
| Date Deposited: | 08 Aug 2007 09:14 |
| Last Modified: | 27 Aug 2021 21:58 |
| URI: | https://usir.salford.ac.uk/id/eprint/160 |
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