A practical radiosynthesis of a tritium-labelled fluoro combretastatin

Hadfield, JA ORCID: https://orcid.org/0000-0001-7984-8319, Hirst, N, Mcgown, A, Lawrence, NJ and Gaukroger, K 2012, 'A practical radiosynthesis of a tritium-labelled fluoro combretastatin' , Journal of Labelled Compounds and Radiopharmaceuticals, 55 (8) , pp. 303-306.

Microsoft Word - Accepted Version Restricted to Repository staff only Download (152kB) | Request a copy

Abstract

Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat.

Item Type:	Article
Themes:	Health and Wellbeing
Schools:	Schools > School of Environment and Life Sciences
Journal or Publication Title:	Journal of Labelled Compounds and Radiopharmaceuticals
Publisher:	John Wiley & Sons
Refereed:	Yes
ISSN:	0362-4803
Related URLs:	Publication
Funders:	Cancer Research UK, Association for International Cancer Research (AICR)
Depositing User:	JA Hadfield
Date Deposited:	31 May 2012 08:50
Last Modified:	27 Aug 2021 22:57
URI:	https://usir.salford.ac.uk/id/eprint/22778

Actions (login required)

Edit record (repository staff only)