An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins

Dupont, M, James, C ORCID: https://orcid.org/0000-0002-0131-7988, Chevalier, J and Pages, JM 2007, 'An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins' , Antimicrobial Agents and Chemotherapy, 51 (9) , pp. 3190-3198.

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Abstract

Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date concerning the early bacterial response to external stresses. Here we report that the expression of ompX, encoding an outer membrane protein, is increased during early exposure to drugs or environmental stresses. At the same time, the level of ompF porin expression is noticeably affected. Because of the role of these proteins in membrane permeability, these data suggest that OmpF and OmpX are involved in the control of the penetration of antibiotics such as β-lactams and fluoroquinolones through the enterobacterial outer membrane. Consequently, the early control of ompX and ompF induced by external stresses may represent a preliminary response to antibiotics, thus triggering the initial bacterial line of defense against antibiotherapy

Item Type:	Article
Themes:	Health and Wellbeing
Schools:	Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title:	Antimicrobial Agents and Chemotherapy
Publisher:	American Society for Microbiology
Refereed:	Yes
ISSN:	0066-4804
Related URLs:	Publication
Funders:	Universite´ de la Me´diterrane´e, Eloi Collery Prix–Acade´mie Nationale de Me´decine, RTN-Marie Curie grant
Depositing User:	Dr Chloe James
Date Deposited:	26 Jan 2015 16:13
Last Modified:	16 Feb 2022 16:05
URI:	https://usir.salford.ac.uk/id/eprint/33334

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