McMahon, SJ., Hyland, WB, Brun, E, Butterworth, KT, Coulter, JA, Douki, T, Hirst, DG, Jain, S, Kavanagh, AP, Krpetic, Z 
ORCID: https://orcid.org/0000-0003-1129-6831, Mendenhall, MH, Muir, MF, Prise, KM, Requardt, H, Sanche, L, Schettino, G, Currell, FJ and Sicard-Roselli, C
2011,
'Energy dependence of gold nanoparticle radiosensitization in plasmid DNA'
, The Journal of Physical Chemistry C, 115 (41)
, pp. 20160-20167.
Abstract
Gold nanopa rticles (GNPs) are of considerableinterest for use as a radiosensitizer, because of their biocompat-ibility and their ability to increase dose deposited because oftheir high mass energy absorption coefficient. Their sensitizingproperties have been verified experimentally, but a discrepancybetween the exper imental results and theoretical predictionssuggests that the sensitizing effect does not depend solely ongold’s superior absorption of energetic photons. Thi s workpresents the results of three sets of experiments that indepen-dently mapped out the energy dependence of the radiosensitiz-ing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use ofmonochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:First, the sensitization is signi ficantly larger than would be predicted; second, it does not vary with energy as would be predicted fromenergy absorption coefficients. These results clearly demonstra te that the effects of GNP-enhanced therapies cannot be predicted byconsidering additional dose alone and that a greater understanding of the processes involved is necessary for the development offuture therapeutics
| Item Type: | Article |
|---|---|
| Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | The Journal of Physical Chemistry C |
| Publisher: | ACS Publications |
| ISSN: | 1932-7447 |
| Related URLs: | |
| Funders: | Cancer Research UK |
| Depositing User: | Dr Zeljka Krpetic |
| Date Deposited: | 11 Oct 2016 14:33 |
| Last Modified: | 27 Aug 2021 23:30 |
| URI: | https://usir.salford.ac.uk/id/eprint/40300 |
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