Withers, SB 
ORCID: https://orcid.org/0000-0002-7021-881X, Forman, R, Meza-Perez, S, Sorobetea, D, Sitnik, K, Hopwood, T, Lawrence, CB, Agace, WW, Else, KJ, Heagerty, AM, Svensson-Fre, M and Cruickshank, SM
2017,
'Eosinophils are key regulators of
perivascular adipose tissue and
vascular functionality'
, Scientific Reports, 7
, p. 44571.
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Abstract
Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in mice deficient in eosinophils, mimicking the obese phenotype, and was restored upon eosinophil reconstitution. Ex vivo studies demonstrated that the loss of PVAT function was due to reduced bioavailability of adiponectin and adipocyte-derived nitric oxide, which was restored after eosinophil reconstitution. Mechanistic studies demonstrated that adiponectin and nitric oxide are released after activation of adipocyte-expressed β3 adrenoceptors by catecholamines, and identified eosinophils as a novel source of these mediators. We conclude that adipose tissue eosinophils play a key role in the regulation of normal PVAT anti-contractile function.
| Item Type: | Article |
|---|---|
| Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | Scientific Reports |
| Publisher: | Nature Publishing Group |
| ISSN: | 2045-2322 |
| Related URLs: | |
| Funders: | Wellcome Trust |
| Depositing User: | Sarah Withers |
| Date Deposited: | 20 Mar 2017 16:11 |
| Last Modified: | 15 Feb 2022 21:50 |
| URI: | https://usir.salford.ac.uk/id/eprint/41640 |
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