Nabavi, N, Bennewith, KL, Churg, A, Wang, Y, Collins, CC and Mutti, L 2017, 'Switching off malignant mesothelioma : exploiting the hypoxic microenvironment' , Genes & Cancer, 7 (11-12) , pp. 340-354.
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Abstract
Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity. The relative unspecific symptoms of mesotheliomas, misdiagnoses, and lack of precise targeted therapies call for a more critical assessment of this disease. In the present review, we categorize commonly identified genomic aberrations of mesotheliomas into their canonical pathways and discuss targeting these pathways in the context of tumor hypoxia, a hallmark of cancer known to render solid tumors more resistant to radiation and most chemo-therapy. We then explore the concept that the intrinsic hypoxic microenvironment of mesotheliomas can be Achilles’ heel for targeted, multimodal therapeutic intervention.
| Item Type: | Article |
|---|---|
| Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | Genes & Cancer |
| Publisher: | Impact Journals |
| ISSN: | 1947-6027 |
| Funders: | Canadian Institutes of Health Research, BC Cancer Foundation Mesothelioma Research Fund/Mitacs Accelerate Postdoctoral Fellowship Fund, Terry Fox New Frontiers Program on Prostate Cancer Progression |
| Depositing User: | USIR Admin |
| Date Deposited: | 14 May 2018 14:07 |
| Last Modified: | 15 Feb 2022 23:17 |
| URI: | https://usir.salford.ac.uk/id/eprint/47004 |
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