Non-infectious status indicated by detectable IgG antibody to SARS-CoV-2

Denning, DW, Kilcoyne, A and Ucer, C 2020, 'Non-infectious status indicated by detectable IgG antibody to SARS-CoV-2' , British Dental Journal, 229 (8) , pp. 521-524.

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A key tenet of protection from infection for dentists is to know who is not infectious. The evidence base regarding protection from respiratory pathogens in dentistry is poor. Those with a positive SARS-CoV-2 IgG antibody are non-infectious (>99% certainty) and can be safely treated with good universal precautions, even for aerosol generating procedures. Viral infectivity with SARS-CoV-2 lasts eight days, unlike viral polymerase chain reaction (PCR) swab tests which can persist for as long as seven weeks. SARS-CoV-2 IgG antibody becomes detectable from 11 days after infection. SARS-CoV-2 IgG antibodies are usually neutralising against the virus and their direct antiviral activity was partially demonstrated in 33,000 patients with COVID-19 treated with convalescent plasma in the USA. So, a positive SARS-CoV-2 IgG antibody is a much more accurate determination of infectiousness than a repeat PCR which is only 70% sensitive. It remains to be seen whether SARS-Cov-2 vaccine responses include protective IgG titres and, once vaccines become widespread, can be used to assist decision-making on appropriate personal protective equipment (PPE) in dentistry.

Item Type: Article
Additional Information: ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1476-5373 **Article IDs: pubmed: 33097885; pii: 10.1038/s41415-020-2228-9; pmc: PMC7582419 **History: accepted 23-09-2020; submitted 17-07-2020
Schools: Schools > School of Health and Society
Journal or Publication Title: British Dental Journal
Publisher: Nature Publishing Group
ISSN: 0007-0610
Related URLs:
SWORD Depositor: Publications Router
Depositing User: Publications Router
Date Deposited: 21 Jan 2021 10:46
Last Modified: 27 Aug 2021 21:47

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