Quantifying and filtering knowledge generated by literature based discovery

Preiss, J ORCID: https://orcid.org/0000-0002-2158-5832 and Stevenson, M 2017, 'Quantifying and filtering knowledge generated by literature based discovery' , BMC Bioinformatics, 18 (Sup. 7) , p. 249.

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Background Literature based discovery (LBD) automatically infers missed connections between concepts in literature. It is often assumed that LBD generates more information than can be reasonably examined. Methods We present a detailed analysis of the quantity of hidden knowledge produced by an LBD system and the effect of various filtering approaches upon this. The investigation of filtering combined with single or multi-step linking term chains is carried out on all articles in PubMed. Results The evaluation is carried out using both replication of existing discoveries, which provides justification for multi-step linking chain knowledge in specific cases, and using timeslicing, which gives a large scale measure of performance. Conclusions While the quantity of hidden knowledge generated by LBD can be vast, we demonstrate that (a) intelligent filtering can greatly reduce the number of hidden knowledge pairs generated, (b) for a specific term, the number of single step connections can be manageable, and (c) in the absence of single step hidden links, considering multiple steps can provide valid links.

Item Type: Article
Schools: Schools > School of Computing, Science and Engineering
Journal or Publication Title: BMC Bioinformatics
Publisher: BioMed Central
ISSN: 1471-2105
Related URLs:
Funders: Engineering and Physical Sciences Research Council (EPSRC)
Depositing User: J Preiss
Date Deposited: 11 Nov 2020 08:48
Last Modified: 16 Feb 2022 05:59
URI: https://usir.salford.ac.uk/id/eprint/58772

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