Scatena, C, Fanelli, G, Fanelli, GN, Menicagli, M, Aretini, P, Ortenzi, V, Civitelli, SP, Innocenti, L, Sotgia, F 
ORCID: https://orcid.org/0000-0003-2826-4529, Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 and Naccarato, AG
2021,
'New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes'
, Scientific Reports, 11 (1)
, p. 2755.
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Abstract
Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little knowledge regarding the expression of sCav-1 at the metastatic sites. We therefore studied sCav-1 expression in IBCs and in their axillary lymph nodes to seek a correlation with cancer metastasis. 189 consecutive invasive IBCs (53 with axillary lymph node metastases and 136 without) were studied by immunohistochemistry, using a rabbit polyclonal anti-Cav-1 antibody. In IBCs sCav-1 was evaluated in fibroblasts scattered in the tumor stroma whereas in lymph nodes sCav-1 was assessed in fibroblast-like stromal cells. For the first time, we observed a statistically significant progressive loss of sCav-1 from normal/reactive axillary lymph nodes of tumors limited to the breast to metastatic axillary lymph nodes, through normal/reactive axillary lymph nodes of tumors with axillary metastatic spread. These data indicate that Cav-1 expressed by the stromal compartment of lymph nodes, somehow, may possibly contribute to metastatic spread in IBC.
| Item Type: | Article |
|---|---|
| Additional Information: | ** From Springer Nature via Jisc Publications Router ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2045-2322 **Article IDs: publisher-id: s41598-021-82405-y; manuscript: 82405 **History: collection 12-2021; published 02-02-2021; online 02-02-2021; registration 20-01-2021; accepted 19-01-2021; submitted 09-05-2020 |
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Scientific Reports |
| Publisher: | Nature Publishing Group UK |
| ISSN: | 2045-2322 |
| Related URLs: | |
| SWORD Depositor: | Publications Router |
| Depositing User: | Publications Router |
| Date Deposited: | 03 Feb 2021 08:47 |
| Last Modified: | 16 Feb 2022 06:39 |
| URI: | https://usir.salford.ac.uk/id/eprint/59475 |
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