Gao, J-M 
ORCID: https://orcid.org/0000-0001-8582-4719, Yi, S-Q, Geng, G-Q, Xu, Z-S ORCID: https://orcid.org/0000-0003-3754-9868, Hide, G ORCID: https://orcid.org/0000-0002-3608-0175, Lun, Z-R and Lai, D-H
2021,
'Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii'
, Parasitology, 148 (6)
, pp. 703-711.
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Abstract
Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with haemoflagellates, such as those in the genus Trypanosoma. We here address whether and how co-infection with trypanosomes can influence T. gondii infection in laboratory models. Rats of five strains, co-infected with T. lewisi, and mice of four strains, co-infected with T. musculi, were found to be more or less susceptible to T. gondii infection, respectively, with corresponding increased or decreased brain cyst burdens. Down-regulation of iNOS expression and decreased NO production or reverse were observed in the peritoneal macrophages of rats or mice, infected with trypanosomes, respectively. Trypanosoma lewisi and T. musculi can modulate host immune responses, either by enhancement or suppression, and influence the outcome of Toxoplasma infection.
| Item Type: | Article |
|---|---|
| Additional Information: | ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1469-8161 **Article IDs: pubmed: 33536085; pii: S0031182021000196 **History: published 04-02-2021 |
| Schools: | Schools > School of Environment and Life Sciences > Biomedical Research Centre |
| Journal or Publication Title: | Parasitology |
| Publisher: | Cambridge University Press |
| ISSN: | 0031-1820 |
| Related URLs: | |
| Funders: | National Science and Technology Major Project of China, National Natural Science Foundation of China, Natural Sciences Foundation of Guangdong Province |
| SWORD Depositor: | Publications Router |
| Depositing User: | Publications Router |
| Date Deposited: | 18 Feb 2021 09:09 |
| Last Modified: | 16 Feb 2022 06:45 |
| URI: | https://usir.salford.ac.uk/id/eprint/59616 |
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