Eldakhakhny, S, Zhou, Q, Crosbie, EJ and Sayan, BS 
ORCID: https://orcid.org/0000-0003-2305-1970
2018,
'Human papillomavirus E7 induces p63 expression to modulate DNA damage response'
, Cell Death and Disease, 9
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Abstract
Cervical cancer is the third most common malignancy diagnosed in women worldwide. The major aetiological factor underlying the malignant transformation of cervical cells is the persistent infection with high-risk human papillomaviruses (HR-HPV), with more than 99% of cases expressing viral sequences. Here, we report a previously unknown mechanism driven by high-risk human papillomavirus E7 protein to modulate response to DNA damage in cervical cancer cells. Our data shows that HR-HPV E7 oncoprotein induces the transcription of the p53-family member p63, which modulates DNA damage response pathways, to facilitate repair of DNA damage. Based on our findings, we proposed a model, where HR-HPV could interfere with the sensitivity of transformed cells to radiation therapy by modulating DNA damage repair efficiency. Importantly, we have shown for the first time a critical role for p63 in response to DNA damage in cervical cancer cells.
| Item Type: | Article |
|---|---|
| Schools: | Schools > School of Environment and Life Sciences |
| Journal or Publication Title: | Cell Death and Disease |
| Publisher: | Springer Nature |
| ISSN: | 2041-4889 |
| Depositing User: | BS Sayan |
| Date Deposited: | 14 Feb 2023 11:45 |
| Last Modified: | 14 Feb 2023 11:45 |
| URI: | https://usir.salford.ac.uk/id/eprint/66327 |
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