Regulation of p73 activity by post-translational modifications

Conforti, F, Sayan, AE, Sreekamur, R and Sayan, BS ORCID: 2012, 'Regulation of p73 activity by post-translational modifications' , Cell Death and Disease, 3 .

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The transcription factor p73 is a member of the p53 family that can be expressed as at least 24 different isoforms with pro- or anti-apoptotic attributes. The TAp73 isoforms are expressed from an upstream promoter and are regarded as bona fide tumor suppressors; they can induce cell cycle arrest/apoptosis and protect against genomic instability. On the other hand, ΔNp73 isoforms lack the N-terminus transactivation domain; hence, cannot induce the expression of pro-apoptotic genes, but still can oligomerize with TAp73 or p53 to block their transcriptional activities. Therefore, the ratio of TAp73 isoforms to ΔNp73 isoforms is critical for the quality of the response to a genomic insult and needs to be delicately regulated at both transcriptional and post-translational level. In this review, we will summarize the current knowledge on the post-translational regulatory pathways involved to keep p73 protein under control. A comprehensive understanding of p73 post-translational modifications will be extremely useful for the development of new strategies for treating and preventing cancer.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Cell Death and Disease
Publisher: Springer Nature
ISSN: 2041-4889
Depositing User: BS Sayan
Date Deposited: 07 Feb 2023 10:44
Last Modified: 07 Feb 2023 10:45

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