MicroRNA control of invasion and metastasis pathways

Sreekumar, R, Sayan, BS ORCID: https://orcid.org/0000-0003-2305-1970, Mirnezami, AH and Sayan, AE 2011, 'MicroRNA control of invasion and metastasis pathways' , Frontiers in Genetics, 2 .

PDF - Published Version
Download (250kB) | Preview


Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastases at diagnosis. This fact highlights the importance of therapeutic approaches targeting cellular invasion and metastasis programs as the next step in cancer treatment. During carcinoma progression a process called epithelial–mesenchymal transition (EMT) results in enhanced invasion and motility which is directly linked with loss of epithelial polarity and epithelial junctions, migration permissive cytoskeleton alterations, and the acquisition of mesenchymal properties. The recent discovery of microRNAs (miRNAs) controlling key cellular pathways has opened a new era in understanding how EMT pathways are modulated. In this review, we classify EMT regulating proteins according to their cellular localization (membrane, cytoplasmic, and nuclear), and summarize the current knowledge on how they are controlled by miRNAs and propose potential miRNAs for the transcripts that may control their expression.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Frontiers in Genetics
Publisher: Frontiers Media
ISSN: 1664-8021
Depositing User: BS Sayan
Date Deposited: 07 Feb 2023 10:52
Last Modified: 07 Feb 2023 11:00
URI: https://usir.salford.ac.uk/id/eprint/66338

Actions (login required)

Edit record (repository staff only) Edit record (repository staff only)