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MP Lisanti

Contact
Biography
My Most Viewed
My Latest

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Contact

Name:

MP Lisanti

Email:

M.P.Lisanti@salford.ac.uk

Department:

School of Science, Engineering & Environment

Organisation:

University of Salford,

Address:

Biomedical Research Centre, 2nd Floor, Rm 202D, 43 Crescent Street, Salford M5 4WT, Greater Manchester

Country:

United Kingdom

Homepage:

https://www.ncbi.nlm.nih.gov/pubmed/?term=lisanti+mp

profile_image:

Biography

Expertise:

Oncology, Ageing, Stem Cell Biology, Breast Cancer, Lung Cancer, Prostate Cancer, Drug Discovery, FDA Drug Repurposing, Mitochondrial Function, Glycolysis, Metabolism, Cancer Metabolism

Job title:

Professor and Chair of Translational Medicine

Biography:

I have been an active research scientist for over 30 years. I began my education at New York University, graduating Magna Cum Laude in Chemistry. I obtained my MD-PhD degrees at Cornell University Medical College in Cell Biology and Genetics. From 1992-96, I was a Fellow at the Whitehead Institute at MIT. After several distinguished appointments at the Albert Einstein College of Medicine and the Kimmel Center, I joined the Breakthrough Breast Cancer Research Unit in 2012 as Professor of Cancer Biology, at The University of Manchester, in the United Kingdom (UK). Following my appointment to the Kimmel Cancer Center in 2006, I was selected for the leadership of the Program in Molecular Biology and Genetics of Cancer. In 2009, I became the Chair of the Department of Stem Cell Biology anmore...

Qualifications:

1981-85: BA in Chemistry, Magna Cum Laude, New York University, New York, USA 1985-92: MD-PhD, Cornell University Tri-Institutional MD-PhD Program (Cornell University, together with Rockefeller University and Memorial Sloan-Kettering), New York, USA 1992-97: Whitehead Institute Fellow, Affiliated with Dr. Harvey Lodish's Laboratory, Whitehead Institute, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA

My Most Viewed

#	Item title
1.	Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways	434	215
2.	Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)	375	638
3.	Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)	349	288
4.	Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth	317	4
5.	Cancer stem cell metabolism	303	199
6.	A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity	274	55
7.	COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?	250	134
8.	Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)	242	281
9.	Current and prospective pharmacotherapies for the treatment of pleural mesothelioma	238	159
10.	Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients : a clinical pilot study	236	186

My Latest

Mauro Lizcano, M, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2022, 'SOX2-high cancer cells exhibit an aggressive phenotype, with increases in stemness, proliferation and invasion, as well as higher metabolic activity and ATP production' , Aging, 14 (24) , pp. 9877-9889.
Bonuccelli, G, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2022, 'Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation' , Aging, 14 (23) , pp. 9466-9483.
Fiorillo, M, Ozsvari, B, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2021, 'High ATP production fuels cancer drug resistance and metastasis : implications for mitochondrial ATP depletion therapy' , Frontiers in Oncology, 11 , p. 740720.
Fiorillo, M, Scatena, C, Naccarato, AG, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2021, 'Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase' , Cell Death and Differentiation, 28 (9) , pp. 2797-2817.
Di Pisa, F, Pesenti, E, Bono, M, Mazzarello, AN, Bernardi, C, Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382, Renzone, G, Scaloni, A, Ciccone, E, Fais, F, Bruno, S, Scartezzini, P and Ghiotto, F 2021, 'SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line' , BMC Molecular and Cell Biology, 22 (1) , p. 41.
Sargiacomo, C, Stonehouse, S, Moftakhar, Z, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2021, 'MitoTracker Deep Red (MTDR) is a metabolic inhibitor for targeting mitochondria and eradicating cancer stem cells (CSCs), with anti-tumor and anti-metastatic activity in vivo' , Frontiers in Oncology, 11 , p. 678343.
De Santis, F ORCID: https://orcid.org/0000-0001-5877-0639, Fucà, G, Schadendorf, D, Mantovani, A ORCID: https://orcid.org/0000-0001-5578-236X, Magnani, L, Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382, Pettitt, S, Bellone, M, Del Sal, G, Minucci, S, Eggermont, A, Bruzzi, P, Bicciato, S ORCID: https://orcid.org/0000-0002-1944-7078, Conte, P, Noberini, R ORCID: https://orcid.org/0000-0002-7267-1079, Hiscott, J, De Braud, F, Del Vecchio, M and Di Nicola, M 2021, 'Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition' , Cytokine & Growth Factor Reviews, 59 , pp. 1-8.
Scatena, C, Fanelli, G, Fanelli, GN, Menicagli, M, Aretini, P, Ortenzi, V, Civitelli, SP, Innocenti, L, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529, Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 and Naccarato, AG 2021, 'New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes' , Scientific Reports, 11 (1) , p. 2755.
Sánchez-Alvarez, R, De Francesco, EM, Fiorillo, M, Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2020, 'Mitochondrial Fission Factor (MFF) inhibits mitochondrial metabolism and reduces breast cancer stem cell (CSC) activity' , Frontiers in Oncology, 10 , p. 1776.
Sotgia, F ORCID: https://orcid.org/0000-0003-2826-4529 and Lisanti, MP ORCID: https://orcid.org/0000-0003-2034-1382 2020, 'Using the common cold virus as a naturally occurring vaccine to prevent COVID-19 : lessons from Edward Jenner' , Aging, 12 (19) , pp. 18797-18803.